Mapping Myeloarchitecture using T2* and Magnetization Transfer¶
Data Acquisition¶
7T MRI at the Harvard Martinos Center for Biomedical Imaging (Boston)
Example of data:
Data Processing¶
Correct artifacts and process T2*:
Use FreeSurfer to reconstruct the surface:
Map T2* values into the cortex of each individual and register to human surface template:
Use Multimodal Information to Study Neuronal Architecture¶
Reproducibility of T2* mapping and distribution across Brodmann areas:
Multimodal mapping:
Study the Effect of Tissue Orientation With Respect to B0¶
Map the orientation of the cortical surface with respect to B0:
Results show an orientation dependence only in regions with high degree of myelination!
References¶
Cohen-Adad J. What can we learn from T2* maps of the cortex? Neuroimage 2013. http://dx.doi.org/10.1016/ j.neuroimage.2013.01.023
Cohen-Adad J, Polimeni JR, Helmer KG, Benner T, McNab JA, Wald LL, Rosen B, Mainero C. T2* mapping and B0 orientation-dependence at 7T reveal cyto- and myeloarchitecture organization of the human cortex. Neuroimage 2012;DOI: 10.1016/j.neuroimage.2012.01.053. PDF